“A na-etinye Baking Soda (Sodium Bicarbonate) nke na-adịghị egbu egbu ma na-emerụ ahụ n'ime 'kapsụl' nano dị nchebe (liposome), a na-etinyekwa tetracycline nwere ike ijikọ ọkpụkpụ n'elu iji banye n'elu ọkpụkpụ. Mgbe osteoclasts bibiri anụ ahụ ọkpụkpụ site na izochi acid, ha nwere ike iwepụta Sodium Bicarbonate ozugbo, na-egbochi ọrụ nke osteoclasts ma na-emezu ebumnuche nke igbochi osteoporosis n'ụzọ bụ isi.” Otu ndị otu nke Prọfesọ Shunwu Fan nke Ngalaba Orthopedics, Run Run Shaw Hospital, Mahadum Zhejiang, na Prọfesọ Ruikang Tang nke Ngalaba Kemistri, Mahadum Zhejiang, bipụtara ihe ha chọpụtara n'oge na-adịbeghị anya na Journal of the American Chemical Society.
Dịka okwu mmalite si kwuo, ọkpụkpụ osteoclast dị ka ahịhịa ndị dị n'osisi ahụ, ha na-arụ ọrụ nke ọma, ọbụna osisi ahụ dị elu, kamakwa n'ihi ire ere na ọdịda ogologo oge. Nnyocha ndị e mere ugbu a kwenyere na isi ihe na-akpata osteoporosis bụ mkpali na-adịghị mma nke ọkpụkpụ osteoclasts, a na-ewerekwa mmepụta acid nke ọkpụkpụ osteoclasts dị ka isi ihe mbụ na-akpata mbibi ọkpụkpụ site na ọkpụkpụ osteoclasts na ihe dị mkpa maka mmebi ha nke anụ ahụ ọkpụkpụ.
Ọgwụ ndị bụ isi n'ọgwụgwọ osteoporosis na-emezu ebumnuche nke mgbochi mmịpụta ọkpụkpụ ma na-akwalite anabolism ọkpụkpụ site n'ilekwasị anya na nhazi nke osteoclast ma ọ bụ osteoblast bayọlọji, mana ha anaghị egbu nzọụkwụ mbụ dị mkpa nke gburugburu acid mpụga nke mmepụta osteoclast site na isi mmalite. Ya mere, ọgwụ ndị dị adị nwere ike ibelata mfu ọkpụkpụ n'ime ndị agadi ruo n'ókè ụfọdụ, mana ọtụtụ mgbe enweghị ike ịgbanwe mbibi ọkpụkpụ kpamkpam nke mere, na iji ọgwụ ndị na-abụghị ọkpụkpụ eme ihe nwekwara ike ibute mmetụta ọjọọ ndị ọzọ na-adịghị mma nke akụkụ ahụ.
Tinyere nke ahụ, ọ bụ ezie na osteoclasts bụ ihe na-akpata osteoporosis, ọtụtụ nnyocha egosila na ha na-arụ ọrụ n'ịkwalite nhazi ọkpụkpụ na angiogenesis dị ka "mkpụrụ ndụ precursor" tupu ha ewepụta acid. Ya mere, ọ dị oke mkpa igbochi osteoclasts nke ọma.
Ndị otu Fan Shunwu na ndị otu Tang Ruikang buru ụzọ mee ka Sodium Bicarbonate liposomes ruo n'elu ọkpụkpụ, na-emepụta oyi akwa nchekwa alkaline, na-eme ka acid nke osteoclasts na-ewepụta ghara ịdị irè, na-egbochi mmegharị osteoclasts na-adịghị mma, na-agbanwekwa nguzozi nke gburugburu ọkpụkpụ iji nweta mmetụta nke ọgwụgwọ osteoporosis.
Lin Xianfeng, dọkịta na-awa ahụ ọkpụkpụ na Run Run Shaw Hospital nke Mahadum Zhejiang, kwuru na nnyocha ahụ chọpụtara na ihe ndị dị na alkaline liposome na gburugburu ebe obibi acidic nke osteoclasts kpatara ọtụtụ apoptosis nke osteoclasts, wee wepụta ọtụtụ vesicles ndị ọzọ na-apụta n'èzí ahụ.” Ọ dị ka otu dominoes, nke a na-akwali otu oyi akwa n'otu oge ma na-eme ka otu nzọụkwụ dịkwuo elu iji guzogide mbibi ọkpụkpụ nke osteoclasts na-eme ka ọ sie ike.
Oge ozi: Jenụwarị-27-2021