"Achịcha Soda na-adịghị egbu egbu na nke na-adịghị emerụ ahụ (Sodium Bicarbonate) bụ enyops in a nano 'capsule' (liposome), na tetracycline nwere ikike na-eme ka ọkpụkpụ na-arịgo n'elu iji nweta adsorb na elu ọkpụkpụ. Mgbe osteoclasts na-ebibi ọkpụkpụ anụ ahụ site na ikpuchi acid, ha nwere ike ịhapụ Sodium Bicarbonate ozugbo, na-egbochi ọrụ nke osteoclasts ma nweta ihe mgbaru ọsọ nke igbochi osteoporosis n'ụzọ bụ isi. ” Otu otu Prọfesọ Shunwu Fan nke Ngalaba Ọkpụkpụ, Run Run Shaw Hospital, Mahadum Zhejiang, na Prọfesọ Ruikang Tang nke Ngalaba Chemistry, Mahadum Zhejiang, bipụtara ihe ha chọpụtara na nso nso a na Journal of the American Chemical Society.
Dị ka okwu mmeghe si kwuo, osteoclasts dị ka termit nke osisi, na-arụ ọrụ otu oge, ọbụnadị osisi toro eto, kamakwa n'ihi ire ere na ọdịda ogologo oge. Ihe omumu nke oge a kwenyere na ihe mbu nke osteoporosis bu ihe ndi ozo nke osteoclasts, a na-ewere ihe omimi nke mmiri site na osteoclasts dika isi ihe mbu nke mbibi ọkpụkpụ site na osteoclasts na ihe dị mkpa dị mkpa maka mbibi nke anụ ahụ ọkpụkpụ.
Isi ọgwụ ndị na-agwọ ọrịa nke osteoporosis na-enweta nzube nke mgbochi ọkpụkpụ na-akwalite ọkpụkpụ anabolism site n'ilekwasị anya na usoro nke osteoclast ma ọ bụ osteoblast biology, mana ha anaghị egbu isi mmalite mbụ nke mpụga acid gburugburu ebe obibi nke osteoclast guzobere site na isi mmalite. Ya mere, ọgwụ ndị dị ugbu a nwere ike belata ọkpụkpụ ọkpụkpụ na ndị agadi ruo n'ókè ụfọdụ, mana mgbe mgbe, ha enweghị ike iweghasị mbibi ọkpụkpụ nke merenụ, na nchịkwa nhọrọ nke ọgwụ ndị na-abụghị ọgwụ nwekwara ike iduga na ebumnuche na mmetụta ndị ọzọ na-egbu egbu nke akụkụ ahụ.
Tụkwasị na nke ahụ, ọ bụ ezie na osteoclasts bụ ihe na-akpata osteoporosis, ọtụtụ ọmụmụ egosiwo na ha na-ekere òkè n'ịkwalite ọkpụkpụ na angiogenesis dị ka "mkpụrụ ndụ precursor" tupu ha ezobe acid. Ya mere, ọ dị ezigbo mkpa igbochi osteoclasts n'ụzọ ziri ezi.
Ndị otu Fan Shunwu na ndị otu Tang Ruikang sụrụ ụzọ na-elekwasị anya nke Sodium Bicarbonate liposomes ka ọkpụkpụ elu, na-eme ihe mkpuchi alkaline, na-egbochi acid nke osteoclasts zoro ezo, na-egbochi ọrụ na-adịghị mma nke osteoclasts, ma na-agbanwezi nhazi nke ọkpụkpụ microenvironment iji nweta mmetụta nke ịgwọ osteoporosis .
Lin Xianfeng, onye dọkịta na-awa ọkpụkpụ na Run Run Shaw Hospital nke Mahadum Zhejiang, kwuru na nyocha ahụ chọpụtara na ihe ndị dị na alkaline liposome na mpaghara acidic nke osteoclasts kpalitere ọtụtụ apoptosis nke osteoclasts, wee wepụta ọtụtụ mkpụrụ vesicles extracellular. "Ọ dị ka set nke dominoes, nke a na-akwagharị otu akwa n'otu oge ma bulie otu nzọụkwụ n'otu oge iji guzogide oke mbibi ọkpụkpụ nke ike nke osteoclasts kpatara."
Post oge: Jan-27-2021